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Apr 21, 2020
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Sep 2, 2020
Published
Dec 28, 2020
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Abstract

Oxalis corniculate and Pteropyrum scoparium are two edible wild Omani plants with known preventive effects on various human diseases, yet their therapeutic role in colon cancer was not studied. Azoxymethane (AOM) is a common oxidizing agent that induces colon cancer in experimental animal models. In the current study, we examined the protective effect of Oxalis corniculate and Pteropyrum scoparium leaves extracts against AOM-induced cancer and oxidative stress in rat colon. Sixty Sprague-Dawley rats were randomly divided into 6 groups (10 rats/group). The Control group was fed a standard diet; the AOM-treated group was fed a standard diet and received an intraperitoneal injection of AOM at a dose of 30 mg/kg body weight for each rat. The other four groups received intragastric intubation of Pteropyrum scoparium or Oxalis corniculate leaves extracts (0.1 mg extract/ 1 mL water/day) in the absence or presence of AOM injection. After 8 weeks, all rats were sacrificed and the colon tissues were dissected for Aberrant Crypt Foci (ACF) enumeration of cancer lesions development, and for measurements of glutathione (GSH), total antioxidant capacity (TAC), and DNA oxidative damage. Our results showed that the AOM-injected rats showed a significant increased level of DNA oxidative damage, lower levels of GSH and TAC, and higher ACF as compared to the control group. Oxalis corniculate and Pteropyrum scoparium leaves extracts significantly suppressed the oxidative damage associated with AOM injection and mitigated its carcinogenic effect in rat colon. Both Oxalis corniculate and Pteropyrum scoparium leaves extracts act as potent antioxidants and combat the AOM-associated oxidative stress and colon carcinogenesis. The data from this study suggest that dietary supplementation of these two wild plants might be applied as a therapeutic agent for colon cancer treatment.

Keywords

Antioxidants Colon cancer Omani Wild Plants Oxidative stress

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Author Biography

Mostafa Ibrahim Waly, Food Science and Nutrition Department CAMS, Sultan Qaboos University

Dr. Mostafa I. Waly is an eminent scientist and academic in the field of Nutritional Biochemistry. He is recognized for his significant contribution to the basic and applied knowledge of therapeutic nutrition and the primary prevention of human chronic diseases. His total SCOPUS, ResearchGate, and Google Scholar citations indicate the high impact of his research in the international scientific community. He received his Ph.D. from Northeastern University (Boston, USA) in 2003 and currently he holds the position of Associate Professor in the Department of Food Science and Nutrition at the College of Agricultural and Marine Sciences, Sultan Qaboos University, Oman.  

How to Cite
Waly, M. I. (2020). Protective effect of Oxalis corniculate and Pteropyrum scoparium Leaves Extracts against Azoxymethane-induced oxidative stress and colon carcinogenesis. Journal of Agricultural and Marine Sciences [JAMS], 26(1), 47–52. https://doi.org/10.24200/jams.vol26iss1pp47-52
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