Pre-Implantation Immunosuppression in the Pregnant Rat:A Possible Role of Seminal Fluid

Omar A. Habbal, John M. McLean

Abstract


Successful reproduction involves exposure of the female in significant antigenic challenge. These experiments were done to test the possibility/hypothesis that seminal fluid has an immunosuppressive role in the early stages cf pregnancy,
which cculd pretect the conceptus from immonological attack. A highly inbred strain cf rat AO(RTI“) was used in this study. Eleven groups of animals were examined, one during the estrous phase of the ovarian cycle to provide base-line data, five during pseudopregnancy, designated as controls, and five groups during syngeneic pregnancy. Each group contained a minimum of six animals. For each animal, body weight and organ/tissue weightsocf the uterus, thymus, uterine and popliteal lymph nodes, were recorded together with total cell counts of the lympocid tissues and their proliferating cell counts. The material was
collected during each of the first five days of pregnancy and pseudopregnancy. The present study supports an immunological suppression by seminal fluid during early pregnancy as shown by a significant sustained depresson of the proliferative lymphocyte response in the uterine regional lymph nodes.


Keywords


NA

Full Text:

PDF

Refbacks

  • There are currently no refbacks.




Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Sultan Qaboos University Medical Journal, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Postal Code 123, Al-Khod, Muscat, Oman

ISSN (Print edition): 2075-051X ISSN (Internet edition): 2075-0528

Copyright SQUMJ 2019. This journal and its content is licensed under a Creative Commons Attribution No Derivatives 4.0 International license.

Flag Counter