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Caudal regression syndrome is a rare fetal condition of diabetic pregnancy. Although the exact mechanism is not known, hyperglycaemia during embryogenesis seems to act as a teratogen. Independently, caudal regression syndrome (CRS), agenesis of the corpus callosum (ACC) and partial lobar holoprosencephaly (HPE) have been reported in infants of diabetic mothers. To our knowledge, a combination of all these three conditions has not been reported so far.


Diabetes in pregnancy Caudal regression syndrome Holoprosencephaly Corpus callosum Case report Oman.

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Al Hashami, H., Bataclan, M. F., Mathew, M., & Krishnan, L. (2010). Caudal Regression Syndrome with Partial Agenesis of the Corpus callosum and Partial Lobar Holoprosencephaly : Case report. Sultan Qaboos University Medical Journal, 10(1), 89–93. Retrieved from

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