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We report the case of a 57-year-old male physician who presented with a life threatening secretory and refractory diarrhoea of around 20 L/day. This was complicated by severe hypotension, hypokalaemia, hypercalcaemia, renal failure requiring dialysis, metabolic acidosis, cardiorespiratory arrest and ventilation for 12 days. His diarrhoea responded immediately to the first dose of a therapeutic trial of subcutaneous octreotide 100 mcg 8 hourly which was started on clinical grounds alone before any investigations were carried out. After one day he was extubated and his blood pressure returned to normal. When a functioning neuroendocrine tumour is suspected clinically, the use of octreotide can, as in this case, be life saving.


VIPoma Diarrhoea Pancreatic tumour Neuroendocrine tumour Octreotide Chromogranin A Cardiopulmonary arrest Case report Oman

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ElShafie, O., Grant, C., Al-Hamdani, A., Jain, R., & Woodhouse, N. (2011). VIPoma Crisis : Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. Sultan Qaboos University Medical Journal, 11(1), 104–107. Retrieved from

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