Transient Myeloproliferative Disorder and Down Syndrome Is there a link?

Zenaida S. Reyes, Wafa Bashir, Anil Pathare

Abstract


An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia. 



Keywords


Extreme premature; Transient myeloproliferative disorder; Down syndrome; GATA1; Acute myelogenous leukemia (AML); Case report; Oman.

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Sultan Qaboos University Medical Journal, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Postal Code 123, Al-Khod, Muscat, Oman

ISSN (Print edition): 2075-051X ISSN (Internet edition): 2075-0528

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