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An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia. 


Extreme premature Transient myeloproliferative disorder Down syndrome GATA1 Acute myelogenous leukemia (AML) Case report Oman.

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Reyes, Z. S., Bashir, W., & Pathare, A. (2012). Transient Myeloproliferative Disorder and Down Syndrome Is there a link?. Sultan Qaboos University Medical Journal, 12(4), 498–502. Retrieved from

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