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Malignant melanoma is predominantly a skin disease but in rare instances it may occur at other sites. A vaginal melanoma is a rare clinical entity and the round cell type is an uncommon variant. Although the present case was clinically diagnosed as a urethral caruncle, on histopathological examination and immunostaining it was diagnosed as a round cell pigmented malignant melanoma. The patient refused radical surgery and was given a full course radiotherapy treatment but died a year later. Malignant vaginal melanoma carries a very poor prognosis even when lesion is localised at the time of presentation. The five-year survival rate ranges from 10–20% with the prognosis being influenced by tumour size. A tumour size ≥3cm has a poor prognosis. Age, mitotic count, stage, and location of the lesion do not influence survival rates.


Melanoma Vagina Malignancy Fontana-Masson stain Immunohistochemical staining Round cell tumors Case report India

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Chauhan, N., Gaur, D. S., & Pathak, V. P. (2012). Round Cell Vaginal Malignant Melanoma : A rare entity. Sultan Qaboos University Medical Journal, 12(4), 508–511. Retrieved from

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