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Guillain-Barre syndrome (GBS) is a recognized complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report two children with GBS associated with SARS-CoV-2 presented to a tertiary center in Muscat, Oman in 2021: The first patient was a 3-month-old female infant who presented with bradypnea, encephalopathy, and generalized weakness that required mechanical ventilation. Polymerase chain reaction (PCR) testing of the nasopharyngeal swabs (NPS) was positive for SARS-CoV-2. She had axonal variant GBS based on a nerve conduction study, cerebrospinal fluid analysis, and neuroimaging findings. The second patient was a 6-year-old girl with fever, vomiting, and diarrhea followed by ascending weakness who presented with quadriplegia and facial weakness. Subsequently, she developed respiratory muscle weakness and required mechanical ventilation. PCR testing of NPS was negative for SARS-Cov-2, however IgG serology analysis was positive. The clinical course of these two patients was rapidly progressive and both of them required mechanical ventilation. The patient with axonal variant GBS made an incomplete recovery.

Keywords: Acute Inflammatory Demyelinating Polyradiculoneuropathy, SARS-CoV-2, Oman

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Al Amrani, F., Al-Abdwani, R. ., Al Rashdi, F., Al Ajmi, E., & Al Futaisi, A. (2022). Guillain-Barre Syndrome Associated with SARS-CoV-2 in Two Pediatric Patients. Sultan Qaboos University Medical Journal, 1(1).