An Unusual Presentation of Choriocarcinoma in A postmenopausal woman: A case report

Abstract

Choriocarcinoma (CC) is a malignant neoplasm of the trophoblastic tissue, with a potential to metastasize to distant organs. A limited case of gestational CC develops after a long latent period. We describe the case of a 52-year-old postmenopausal woman who developed metastatic choriocarcinoma presumably of gestational origin, 8 years after the last pregnancy, and 2 years after the last menstrual period. The patient was diagnosed with CC metastatic to the brain, spleen, lung and the kidney. The β-human chorionic gonadotrophin level was found to be raised (1,292,867 mIU/mL). The International Federation of Gynecologic Oncology (FIGO) risk score was calculated to be 14 (very high risk). The patient was initially treated with whole-brain radiotherapy (WBRT) and splenic artery embolization because of a hemoperitoneum. Afterwards the patient received systemic treatment using the standard EMA/CO regimen till complete serological remission.

Keywords: Choriocarcinoma; Postmenopausal; Latent period; Brain; Oman.