Clinicopathological Features and Outcomes of Endometrial Cancer: A single institution experience

Abstract

Objective: Endometrial cancer (EC) is the 6th most common cancer in women worldwide, and the 5th most common cancer in women in Oman. Survival outcomes of EC have not been reported previously from Oman. We report the demographic features, clinical presentation, pathological types, and long-term outcomes of patients diagnosed with EC in Oman. Methods: A retrospective analysis was carried out on consecutive patients treated at a single tertiary referral center in Oman. Survival was estimated using the method of Kaplan and Meier. Results: A total of 50 consecutive patients with EC were included. Median age was 61 years (range 31-86 years), 72% had type I histology. Most patients were diagnosed to have stage IA and IB (49% and 20%) respectively, and the majority of patients had grade 1 or 2 tumors (40% and 34%) respectively. Overall, the 5-year survival was estimated to be 70%, and the 10-year survival rate was 56%. Weight (> 75 kg) and BMI (>30kg/m²) were significantly associated with a better survival. Tumor histology (Type I vs Type II or carcinosarcoma), grade (1 vs 2 vs 3), and stage (IA or IB vs II-IV) were associated with better overall survival (p=0.007, <0.0001, and <0.0003 respectively). Patients with EC with co-morbidities, other than obesity, had inferior survival compared to those who did not had co-morbidities. Conclusion: Median age at presentation, histological sub-type, clinical stage, and outcomes are comparable to the published literature. Almost two-thirds of the patients were obese. These data could be used as a benchmark for outcomes of EC in the region.

Keywords: Endometrial Cancer; Endometroid type, obesity and cancer; Oman.