Severe Hemolysis in Glucose 6 Phosphate Dehydrogenase Deficiency Secondary to Dengue Fever: Analysis of 3 cases from Oman

Abstract

Dengue is a viral fever transmitted by Aedes species of mosquitoes. Globalization has led to worldwide spread of DF including Oman. High incidence of Glucose 6 phosphate deficiency (G6PD) is present in the population, often undiagnosed.  We report three patients admitted in tertiary care hospital in Muscat, Oman with Dengue Fever (DF) that later triggered hemolysis. It proved fatal in one case and caused irreversible renal damage requiring dialysis in other. Both DF and G6PD deficiency can cause bleeding. Both need supportive treatment and avoiding incriminating factors.   G6PD deficiency with concomitant viral infections have been reported to increase morbidity and mortality. Hemolysis triggered due to DF in G6PD deficient has not be reported in literature. If the clinical course or hemolytic pattern in DF deviates from expected, an associated hemolytic disorder should be considered especially in regions with high prevalence.