@article{Al-Shamahy_Sabrah_Al-Robasi_Naser_2012, title={Types of Bacteria associated with Neonatal Sepsis in Al-Thawra University Hospital, Sana’a, Yemen, and their Antimicrobial Profile}, volume={12}, url={https://journals.squ.edu.om/index.php/squmj/article/view/1649}, abstractNote={<span>Objectives:</span><span> This study was undertaken to investigate the organisms causing sepsis in the Neonatal Unit at Al-Thawra Hospital, Sana’a, Yemen, determine their resistance to antibiotics, and recommend policy for empirical treatment. </span><span>Methods:</span><span> A total of 158 neonates having one or more signs of sepsis, and aged from 0 to 28 days, were enrolled in this study. A blood sample was taken from each subject, cultured, and then antibacterial susceptibility tests were performed for isolates. </span><span>Results:</span><span> 90 (57%) cases yielded positive cultures. Early-onset sepsis showed higher positive culture results (61.7%) than late-onset sepsis (32%). Significant positive culture results were found among the group with birth weight 0.9–2 Kg (78.6%). Gram negative bacteria constituted 97.8% of the total isolates, of which Klebsiella pneumoniae was the predominant pathogen (36.7%), followed by Pseudomonas species (30.0%). The commonest symptoms among the cases were respiratory distress (72.2%), jaundice (62.2%), cyanosis (51.1%), and lethargy (47.8%); the mortality rate was 27.8%. All Gram negative bacterial isolates were sensitive to imipenem and some isolates were sensitive to fourth-generation cephalosporins, but most isolates were highly resistant to the majority of other antibiotics tested. </span><span>Conclusion: </span><span>Gram negative organisms were the most frequent causative agents of bacterial sepsis, which is a significant cause of mortality and morbidity in the newborn, and particularly in those of very low birth weight. It can also be concluded that imipenem and fourth-generation cephalosporins can be used for empirical treatment of bacterial sepsis.</span><br /><br />}, number={1}, journal={Sultan Qaboos University Medical Journal}, author={Al-Shamahy, Hassan A and Sabrah, Amal A and Al-Robasi, Abdul Baki and Naser, Samarih M}, year={2012}, month={Feb.}, pages={48–54} }