TY - JOUR AU - Alhadi, Hafidh A AU - Fox, Keith A A PY - 2010/04/01 Y2 - 2024/03/29 TI - Heart-Type Fatty Acid-Binding Protein in the Early Diagnosis of Acute Myocardial Infarction : The potential for influencing patient management JF - Sultan Qaboos University Medical Journal JA - Sultan Qaboos Univ Med J VL - 10 IS - 1 SE - Original Studies DO - UR - https://journals.squ.edu.om/index.php/squmj/article/view/1450 SP - 41-49 AB - <strong><em>Objectives:</em></strong><span> The objective of this study was to evaluate the diagnostic value of heart-type fatty acid-binding protein (H-FABP) in patients with acute chest pain and compare it with standard cardiac markers. </span><strong><em>Methods:</em></strong><span> We undertook a prospective evaluation of 100 consecutive patients admitted with acute chest pain suggestive of acute coronary syndromes (ACS). Serum cardiac troponin I (cTnI), cardiac troponin T (cTnT), creatine kinase-MB (CK-MB) mass, myoglobin, and H-FABP were determined at presentation and 2, 4, 8–10, and 16–24 hours after presentation. The main outcome measure was the best sensitivity value within 6 hours after symptom onset. </span><strong><em>Results:</em></strong><span> H-FABP peak concentration occurred at 8 hours after symptoms onset and was the most sensitive early marker with 79.9% and 98% of patients with AMI identified at presentation and 2 hours after presentation respectively. The sensitivity of all other cardiac markers (CK-MB mass, cTnI, cTnT, and myoglobin) at presentation was &lt; 62%. The negative predictive value of H-FABP (94%) was also superior to other markers within the first 2 hours of presentation. Myoglobin was the second most sensitive early marker at presentation. Peak sensitivity of cTnI, CK-MB mass, and cTnT were present at 4, 8–10, and 8–10 hours respectively after presentation. </span><strong><em>Conclusion:</em></strong><span>Combined measurement of H-FABP and cTnI on two occasions during the first 8 hours after symptom onset was sufficiently sensitive and specific for the early diagnosis of most patients with acute MI and may provide advantages over other cardiac marker combinations.</span><br /><br /><br /> ER -