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Abstract
A new screening technique for obstructive sleep apnea (OSA) is implemented. This technique is based on finding the statistical signal characterization (SSC) parameters of the spectrum of pre-processed R-R-interval (RRI) data. A single classification factor (CR) is selected to classify between patients with obstructive sleep apnea and normal controls. Both nonparametric spectral analysis techniques (with Welch method as an example) and parametric techniques (with Burg method as an example) are used to estimate the power spectral density. The data tested in this work are drawn from MIT database. Both trial and test (challenge) groups of data are used. Each of these two groups contains 20 OSA and 10 normal records. The trial data is used to set the threshold value of the classification factor, which is then used in identifying the challenge data. The total accuracy of the screening is about 93% and 90% using Burg and Welch algorithms respectively.
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References
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- Cardiac Interbeat Interval Time Series," Computers in Cardiology , Vol. 27, pp.753-756.
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References
AASM Task Force Report, 1999, "Sleep –Related Breathing Disorders in Adults, Recommendations for Syndrome Definition and Measurement Techniques in Clinical Research," Sleep , Vol. 22, pp. 667-689.
Bigger, T., 2000, "Overview of RR Variability, Heart Rhythm Instruments," Inc, 2002. Available: http://www.nervexpress.co m.
Boyer, S. and Kapur, V., 2002, "Obstructive Sleep Apnea: its Relevance in the Care of Diabetic Patients," Clinical Diabetes , Vol. 20(3), pp. 126- 132.
Drinnan, M., Aller, J., Langley, P. and Murray, A., 2000, "Detection of Sleep Apnea from Frequency Analysis of Heart rate Variability," Computers in Cardiology , Vol. 27, pp. 259 -262.
Friesen, G.M., Jannett, T.C., Jadallah, M.A., Yales, S.L., Quint, S. R. and Nagle, H.T., 1990, "A Comparison of the N oise Sensitivity of N ine QRS Detection Algorithms,” IEEE Trans. Biomed. Eng. , Vol. 37(1), pp. 85 -97.
Hirsch, H.L.,1992, "Statistical Signal Charact erization," Artech House, Norwood, MA, USA.
Kay, S.M., 1988, "Modern Spectral Estimation," Englewood Clis, NJ : Prentice Hall.
Khoo, M., Kim, T. and Berry, R., 1999, "Spectral Indices of Cardiac Autonomic Function in Obstructive Sleep Apnea," Sleep , Vol. 22(4), pp. 443-451.
Marple, S.L., 1987, "Digital Spectral Analysis," Englewood Clis, NJ : Prentice Hall.
Mietus, J., Peng, C., Ivanov, P. and Goldberger, A.I., 2000, "Detection of Obstructive Sleep Apnea from
Cardiac Interbeat Interval Time Series," Computers in Cardiology , Vol. 27, pp.753-756.
Netzer, N., "Overnight P ulse Oximetry for Sleep- Disordered Breathing in Adults," Chest , Aug., 2001, pp. 625 -633.
Pack, A.I., 1993, "Simplifying the Diagnosis of Obstructive Sleep Apnea, " Annals of Internal Medicine, Vol. 119( 6), pp. 528-529.
Penzel, T., 2000, "The Apnea ECG D atabase," Computers in Cardiology , Vol. 27, pp. 255 -258.
Penzel, T., McNames, J., de Chazal, P., Raymond, B., Murray, A. and Moody, G., 2002, "Systematic C omparison of different Algorithms for Apnoea Detection based on Electrocardiogram R ecordings," Med. Biol. Eng.
Comput. , Vol. 40, pp. 402 -407.
PhysioNet: An NIH/NCRR Research Resource for Complex Physiologi c Signals, apnea ecg data
files online. Available: physionet.org/physiobank/database/apnea –ecg PhysioNet: An NIH/NCRR Research Resource for Complex Physiological Signals, QRS Detection and Waveform Boundary Recognition using Ecgpuwave, Computer Program. Avail able: http//www.physionet.org/physiotools /ecgpuwave
Proakis, J.G. and Manolakis, D.G., 2000, "Digital Signal Processing: Principles , Algorithms, and
Applications, " 3rd Ed, Prentice -Hall of India .
Rangayyan, R.M., 2000, "Biomedical Signal Analysis: A Case -Study Approach," IEEE Press.
Rodenstein, D.O., Doom, G., Thomas, Y., Luestro, G., Stanescu, D.C., Culee, C. and Aubert - Tulkens, G., 1990, "Pharyngeal S hape and Dimensions in H ealthy Subjects, Snores, and Patients with Obstructive Sleep Apnea," Thorax , Vol. 45, pp. 722-727.
Stevenson, J.E., (2003), "Diagnosis of Sleep Apnea," Wisconsin Medical J . Vol. 102(1), pp. 25-27.
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology, 1996, "Heart Rate Variability; Standard of Measurements, Physiological Interpretation, and Clinical Use," Circulation, Vol. 93, pp. 1043-1065.
Tsi, W.H., Flemons, W.W., Whitelaw, W.A. and Remmers, J.E., 1999, "A Comparison of Apnea- Hypoapnea Indices Derived from different definitions of Hypoapnea, " Am J. Respir. Crit. Care Med ., Vol. 159, pp. 43 -48.