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Abstract
The isolation and structural elucidation of aristolochic acid-A and aristolochic acid-D from Omani Aristolochia bracteolata plant is reported. Antioxidant activities of these two natural products were evaluated for their capacity to reduce Mo(VI) to Mo(V). The study revealed that aristolochic acid-D is more active than vitamin C while aristolochic acid-A has activity similar to vitamin C.
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References
- ARUOMA, O.I. 1998. Free radicals, oxidative stress, and antioxidants in human health and disease. J. Am.Oil Chemists’ Soc., 75: 199-212.
- CHAKRAVARRY, M.; CHAUDHURI, C.; ACHARI, B. and PAKRASHI, S.C. 1988. Studies on Indian medicinal plants. Part 90. N-acetylnornuciferine and other constituents of Aristolochia bracteata. Planta Med., 54(5): 467-468.
- El TAHIR, K.E. 1991. Pharmacological actions of magnoflorine and aristolochic acid-1 isolated from the seeds of Aristolochia bracteata. Int. J. Pharmacogn, 29(2): 101-110.
- GHAZANFAR, S.A. 1992, An Annotated Catalogue of the Vascular Plants of Oman. Scripta Bot. Belg. 2:20
- HOUGHTON, P.J. and OGUTYEREN, M. 1990. Aristolochic acids and aristolactams from Aristolochia auricularia. Phytochem., 30(1): 253-254.
- JIANGSU. 1977. New Medicine College. Encyclopedia of Chinese Materia Medica, 1: 294.
- KUPCHAN, S.M. and MERIANOS, J.J. 1968. The isolation and structural elucidation of novel derivatives of aristolochic acid from Aristolochia indica. J. Org. Chem., 33(10): 3735-3788.
- MATSUO, S.; YUZAWA, Y.; HANAKI, S.; MORITA, Y.; MIZUNO, M.; MARUYAMA, S. and LIU, M. 2003. The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. Clinical and Experimental Nephrology, 7(3): 186-194.
- MOHAMED, O.A.; WANG, Z.; Yu, G.; KHALID, H.E. and ABU-ELRISH, B.I. 1999. Determination of aristolochic acid-A in the roots and rhizomes of Aristolochia from Sudan and China by HPLC. Zhongguo Yaoke Daxue Xuebao, 30(4): 288-290.
- PRIESTAP, H.A. 1987. Minor aristolochic acids from Aristolochia Argentina and mass spectral analysis of aristolochic acids. Phytochem., 26(2): 519-529
- PRIETO, P.; PINEDA, M. and AGUILAR, M. 1999. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex. Anal. Biochem., 269: 337-341.
- TIAN-SHUNG Wu; LI-FEI Ou and CHE-MING TENG. 1994. Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis. Phytochem., 36(4): 1063-1068.
- YINRONG, Lu and FOO, Y.L. 2001. Antioxidant activities of polyphenols from sage (Salvia officinalis). Food Chem., 75: 197-202.
References
ARUOMA, O.I. 1998. Free radicals, oxidative stress, and antioxidants in human health and disease. J. Am.Oil Chemists’ Soc., 75: 199-212.
CHAKRAVARRY, M.; CHAUDHURI, C.; ACHARI, B. and PAKRASHI, S.C. 1988. Studies on Indian medicinal plants. Part 90. N-acetylnornuciferine and other constituents of Aristolochia bracteata. Planta Med., 54(5): 467-468.
El TAHIR, K.E. 1991. Pharmacological actions of magnoflorine and aristolochic acid-1 isolated from the seeds of Aristolochia bracteata. Int. J. Pharmacogn, 29(2): 101-110.
GHAZANFAR, S.A. 1992, An Annotated Catalogue of the Vascular Plants of Oman. Scripta Bot. Belg. 2:20
HOUGHTON, P.J. and OGUTYEREN, M. 1990. Aristolochic acids and aristolactams from Aristolochia auricularia. Phytochem., 30(1): 253-254.
JIANGSU. 1977. New Medicine College. Encyclopedia of Chinese Materia Medica, 1: 294.
KUPCHAN, S.M. and MERIANOS, J.J. 1968. The isolation and structural elucidation of novel derivatives of aristolochic acid from Aristolochia indica. J. Org. Chem., 33(10): 3735-3788.
MATSUO, S.; YUZAWA, Y.; HANAKI, S.; MORITA, Y.; MIZUNO, M.; MARUYAMA, S. and LIU, M. 2003. The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. Clinical and Experimental Nephrology, 7(3): 186-194.
MOHAMED, O.A.; WANG, Z.; Yu, G.; KHALID, H.E. and ABU-ELRISH, B.I. 1999. Determination of aristolochic acid-A in the roots and rhizomes of Aristolochia from Sudan and China by HPLC. Zhongguo Yaoke Daxue Xuebao, 30(4): 288-290.
PRIESTAP, H.A. 1987. Minor aristolochic acids from Aristolochia Argentina and mass spectral analysis of aristolochic acids. Phytochem., 26(2): 519-529
PRIETO, P.; PINEDA, M. and AGUILAR, M. 1999. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex. Anal. Biochem., 269: 337-341.
TIAN-SHUNG Wu; LI-FEI Ou and CHE-MING TENG. 1994. Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis. Phytochem., 36(4): 1063-1068.
YINRONG, Lu and FOO, Y.L. 2001. Antioxidant activities of polyphenols from sage (Salvia officinalis). Food Chem., 75: 197-202.