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Objectives: This study aimed to assess the ankle brachial index (ABI) as a predictor of peripheral arterial diseases (PAD) in children with steroid-resistant nephrotic syndrome (NS). Methods: Twenty children (11 males and 9 females) attending the Pediatric Nephrology Outpatient Clinic of El-Minia University Hospital, Egypt, were enrolled in this study. Their age ranged between 5 and 15 years with a mean of 10.75 ± 3.31 years. They had proteinuria and were dependent on steroid therapy. Twenty healthy age- and sex-matched children served as a control group. All patients and controls underwent a thorough history-taking and clinical examination. All subjects in the study underwent laboratory investigations, including a urine analysis (24-hour test for protein in urine, and levels of serum urea and creatinine, triglycerides, and cholesterol). A renal biopsy was done to diagnose the children’s histopathological type of NS. A Doppler study was done to determine patients’ ABI. Results: ABI was significantly higher in the patient group than in the control group (P <0.0001). There was a negative correlation between ABI and duration of treatment (r value = 0.77 and P <0.001). Conclusion: ABI is simple non-invasive manoeuvre that can reliably assess arterial stiffness as an early predictor of atherosclerosis in nephrotic patients with long duration of both illness and steroid therapy.


Ankle brachial index Children Steroid resistant Nephrotic syndrome Egypt.

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Mohamed, S. M., Elmazary, A., & Taha, H. T. (2013). Ankle Brachial Index in Children with Steroid-Resistant Nephrotic Syndrome. Sultan Qaboos University Medical Journal [SQUMJ], 13(1), 88–92. Retrieved from