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Empyema can rarely complicate pneumonia in neonates; it has a high morbidity and mortality in this population. We report a two-month-old healthy term male neonate who presented with fever, mild shortness of breath and reduced feeding to a tertiary care hospital in Muscat, Oman, in 2021. Investigations revealed the presence of Haemophilus influenzae empyema. He was managed with video-assisted thoracoscopic surgery and prolonged course of antibiotics. A follow-up at the end of the antibiotic course revealed complete symptom resolution with a repeated chest x-ray showing significant right chest opacity improvement. A baseline immune work-up was done and was reported to be within normal ranges.

Keywords: Empyema; Neonate; Haemophilus Influenzae; Case Report; Oman.

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How to Cite
Al-Yazeedi, S., Al-Farsi, R., Al-Rawahi, H., & Al Yazidi, L. S. (2023). Haemophilus Influenzae Empyema in a Two-Month-Old Infant. Sultan Qaboos University Medical Journal, 23(3), 394–396.