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Abstract

Objectives: This study aimed to evaluate the efficacy of Penile Girth Enhancement (PGE) using Amniotic Membrane (AM) as a graft in a rabbit model. Additionally, stereological studies were used to obtain quantitative histological data regarding the structure of the penis. Methods: In this study, 20 adult male rabbits of similar age and weight were allocated to two sham and surgery+AM groups. Both groups underwent surgery by longitudinal Ishape midline incision of the tunica albuginea on the dorsal surface of the penis. The surgery +AM group underwent PGE by AM graft. The penile length and mid circumference were measured using a Vernier caliper before and two months after the surgery. Stereological studies were used to obtain quantitative histological data regarding the structure of the penis. Results: The mean total volume and diameter of the penis increased in the surgery +AM group (p<0.03 and p<0.04, respectively). The stereological evaluation showed a significant increase in the mean volumes of the tunica albuginea and corpora cavernosa in the surgery +AM group compared to the sham group (p<0.01, p< 0.03). Additionally, the mean volume density of the collagen bundles, muscle fibers, and cavernous sinuses and the total number of fibroblasts and smooth muscle cells increased in the surgery +AM group compared to the sham group (p<0.01, p<0.01, p<0.03, p<0.01, and p<0.05, respectively). No infections, bleedings, or other complications were seen. Conclusions: AM is a method that has appeared promising for material use in penile enhancement. Thus, it may be used for PGE in the future.


Keywords: Amniotic Membrane; Histopathology; Animal; Penile Girth Enhancement.

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How to Cite
Ariafar, A., Karbalay-Doust, S., Ahmed, F., Eslahi, A., & Tayebi, S. (2022). Penile Girth Enhancement using Amniotic Membrane in a Rabbit Model: A stereological study. Sultan Qaboos University Medical Journal, 1(1). https://doi.org/10.18295/squmj.9.2022.053