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Acute dystonic reactions (ADR) are extrapyramidal effects that usually occur after the initiation of a wide variety of drugs or triggering factors besides neuroleptics. We report the case of a 54-year-old man who was admitted with an approximately 10-hour history of muscle twitching around the eyes, face and neck after he took the first dose of oral chloroquine phosphate (1 g [600 mg base]) prescribed for uncomplicated malaria. He was given intravenous diazepam (10 mg statum) followed by 10 mg of oral diazepam 3 times a day. The symptoms improved within 30 minutes of treatment, and he was discharged 14 hours later after a complete recovery.


Dystonia Reactions acute Malaria Chloroquine Administration Oral Case Report Nigeria

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Busari, O. A., Fadare, J., Agboola, S., Gabriel, O., Elegbede, O., & Oladosu, Y. (2013). Chloroquine-induced Acute Dystonic Reactions after a Standard Therapeutic Dose for Uncomplicated Malaria. Sultan Qaboos University Medical Journal, 13(3), 476–478. Retrieved from

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