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Rosai-Dorfman disease (RDD) is a rare benign proliferative histiocytic disorder characterised by massive lymphadenopathy. While extranodal involvement can occur in generalised RDD, isolated soft tissue RDD (STRDD) is extremely rare. We report a 17-year-old male patient who presented to the maxillofacial outpatient department of the Sultan Qaboos Hospital, Salalah, Oman, in 2015 with a painless cheek mass which had been slowly growing over the previous two months. Routine histopathological examinations and immunohistochemistry confirmed a diagnosis of STRDD. Currently, surgical excision is considered to be the most effective curative treatment for STRDD, as the outcomes of other treatment modalities are still unknown. Despite its rarity, STRDD should be considered in the differential diagnosis of histiocytic soft tissue lesions.


Histiocytosis Rosai-Dorfman Disease Emperipolesis S100 Proteins Case Report Oman.

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Rajib, R. C., Pillai, R., Sulaiman, I. A., & Al-Haddabi, I. (2018). Soft Tissue Rosai-Dorfman Disease: Case report. Sultan Qaboos University Medical Journal, 17(4), 452–454.

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